Your browser doesn't support javascript.
loading
Implication of European-derived adiposity loci in African Americans.
Hester, J M; Wing, M R; Li, J; Palmer, N D; Xu, J; Hicks, P J; Roh, B H; Norris, J M; Wagenknecht, L E; Langefeld, C D; Freedman, B I; Bowden, D W; Ng, M C Y.
Afiliación
  • Hester JM; Center for Diabetes Research, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
Int J Obes (Lond) ; 36(3): 465-73, 2012 Mar.
Article en En | MEDLINE | ID: mdl-21750520
ABSTRACT

OBJECTIVE:

Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with adiposity in European-derived study populations. Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans.

METHODS:

A total of 46 representative single-nucleotide polymorphisms (SNPs) in 19 loci that were previously reported in GWAS in Europeans (including FTO and MC4R) were genotyped in 4992 subjects from six African-American cohorts. These SNPs were tested for association with body mass index (BMI) after adjustment for age, gender, disease status and population structure in each cohort. Meta-analysis was conducted to combine the results.

RESULTS:

Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005allele. The most significantly associated SNPs (rs9424977, rs3101336 and rs2568958) are located in the NEGR1 gene (P=0.005, 0.020 and 0.019, respectively).

CONCLUSION:

We replicated the association of variants at four loci in six African-American cohorts that demonstrated a consistent direction of association with previous studies of adiposity in Europeans. These loci are all highly expressed in the brain, consistent with an important role for central nervous system processes in weight regulation. However, further comprehensive examination of these regions may be necessary to fine map and elucidate for possible genetic differences between these two populations.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Negro o Afroamericano / Peso Corporal / Población Blanca / Diabetes Mellitus Tipo 2 / Obesidad Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Int J Obes (Lond) Asunto de la revista: METABOLISMO Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Negro o Afroamericano / Peso Corporal / Población Blanca / Diabetes Mellitus Tipo 2 / Obesidad Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Int J Obes (Lond) Asunto de la revista: METABOLISMO Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos