Combinatorial patterns of histone modifications in Saccharomyces cerevisiae.
Yeast
; 28(9): 683-91, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-21815215
ABSTRACT
Histone modification is an important subject of epigenetics that plays an intrinsic role in transcriptional regulation. It has been suggested that multiple histone modifications act in a combinatorial fashion to form a 'histone code'. In this study, the combinatorial patterns of histone modifications were studied by using a Bayesian network at the level of individual nucleosomes in S. cerevisiae. Our results indicated that there were 23 combinatorial patterns for 12 histone modifications investigated when a general Bayesian network was constructed. Meanwhile, different networks were also constructed for the genes with high transcript levels (H-network) and low transcript levels (L-network), respectively. Comparison among the general network, H-network and L-network illustrated four conserved combinations H2BK16Ac â H3K4me3; H3K14Ac â H3K4me3; H2AK7Ac â H3K14Ac; and H4K12Ac â H3K18Ac. The detailed analysis for some combinations demonstrated that the combinations were ascribed to some histone-modifying enzymes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
/
Histonas
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Procesamiento Proteico-Postraduccional
/
Proteínas de Saccharomyces cerevisiae
Idioma:
En
Revista:
Yeast
Asunto de la revista:
MICROBIOLOGIA
Año:
2011
Tipo del documento:
Article