Antimicrobial, antileishmanial and cytotoxic compounds from Piper chaba.
Nat Prod Res
; 26(11): 979-86, 2012.
Article
en En
| MEDLINE
| ID: mdl-21834629
ABSTRACT
The petroleum ether and chloroform extracts of the root of Piper chaba showed antimicrobial, antileishmanial and cytotoxic activities. Further bioactivity-guided fractionation led to the isolation of Bornyl piperate (1), piperlonguminine (2) and piperine (3). This is the first report of isolation of compounds (1) and (2) from P. chaba. It was observed that the isolated compounds (1 and 2) showed potent antifungal activity when compared with standard drug Nystatin, and significant cytotoxic activity with the IC50 values of 0.76 and 0.83 µg mL⻹, respectively. These compounds were also found to have weak antibacterial and antileishmanial activities. This is the first report about the antileishmanial activity of Piper isolates.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piper
/
Leishmania
/
Antiinfecciosos
/
Antiprotozoarios
Límite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Bangladesh