Pharmacokinetics of buccal and intranasal lorazepam in healthy adult volunteers.
Eur J Clin Pharmacol
; 68(2): 155-9, 2012 Feb.
Article
en En
| MEDLINE
| ID: mdl-21837394
ABSTRACT
PURPOSE:
To investigate the plasma-concentration profile of lorazepam when administered by the intranasal and buccal routes to determine their utility for the treatment of prolonged seizures.METHODS:
On two occasions separated by at least 7 days washout, 12 healthy adult male volunteers received 2 mg of lorazepam via the intranasal or buccal route. Blood samples were collected at time periods from 0 to 48 h, and pharmacokinetic parameters were determined.RESULTS:
Lorazepam was well absorbed from both administration routes; however, there was a more pronounced lag phase with the buccal route and absorption was more rapid from the intranasal route.CONCLUSIONS:
Intranasal lorazepam has more favourable pharmacokinetics than buccal lorazepam when considering the need for the rapid blood concentrations required for seizure termination. Further clinical evaluation of this route is required.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lorazepam
/
Anticonvulsivantes
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Clin Pharmacol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Reino Unido