Dermatoscopy of facial actinic keratosis, intraepidermal carcinoma, and invasive squamous cell carcinoma: a progression model.
J Am Acad Dermatol
; 66(4): 589-97, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-21839538
ABSTRACT
BACKGROUND:
Little is known about the dermoscopic features of keratinocyte skin cancer.OBJECTIVE:
We sought to determine the dermoscopic features of facial actinic keratosis (AK), intraepidermal carcinoma (IEC), moderately to poorly differentiated invasive squamous cell carcinoma (SCC), and well-differentiated SCC of the keratoacanthoma type.METHODS:
This was a retrospective analysis of dermoscopic images of histopathologically diagnosed keratinocyte skin cancer.RESULTS:
A total of 243 (70 AK, 71 IEC, 78 SCC, and 24 keratoacanthomas) tumors of the face from 243 patients (mean age 71.1 years; range 44-94 years) were analyzed. The majority of patients had a fair skin type, history of melanoma or nonmelanoma skin cancer, and multiple AK. A red pseudonetwork was significantly associated with AK (P < .001), whereas dotted/glomerular vessels, diffuse yellow opaque scales, and microerosions were significantly more prevalent among IEC (P < .001). Hairpin vessels, linear-irregular vessels, targetoid hair follicles, white structureless areas, a central mass of keratin, and ulceration were significantly associated with invasive SCC (P < .001 for all criteria). Similar patterns as in SCC were observed among keratoacanthomas.LIMITATIONS:
The retrospective design of our study and the lack of assessment of sensitivity and specificity of the dermoscopic criteria are limitations.CONCLUSIONS:
Based on our findings we propose a progression model of facial AK developing into IEC and invasive SCC.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
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Carcinoma de Células Escamosas
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Dermoscopía
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Dermatosis Facial
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Queratosis Actínica
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Queratoacantoma
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Austria