Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.
Antiviral Res
; 92(2): 369-71, 2011 Nov.
Article
en En
| MEDLINE
| ID: mdl-21854808
ABSTRACT
Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular α-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10-18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10-18 or its derivatives as antiviral agents to treat servere dengue virus infections.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Dengue
/
Inhibidores Enzimáticos
/
Inhibidores de Glicósido Hidrolasas
Límite:
Animals
Idioma:
En
Revista:
Antiviral Res
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos