Radiolytic reduction characteristics of artificial oligodeoxynucleotides possessing 2-oxoalkyl group or disulfide bonds.
J Nucleic Acids
; 2011: 816207, 2011.
Article
en En
| MEDLINE
| ID: mdl-21860782
ABSTRACT
A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the molecular design of artificial ODNs that are activated by X-irradiation and their applications to regulation of hybridization properties, conformation change, radiation-activated DNAzyme, and decoy molecules.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Nucleic Acids
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón