Aging promotes amyloid-ß peptide induced mitochondrial dysfunctions in rat brain: a molecular link between aging and Alzheimer's disease.
J Alzheimers Dis
; 27(4): 753-65, 2011.
Article
en En
| MEDLINE
| ID: mdl-21876248
ABSTRACT
The entangled relationship of brain aging, mitochondrial dysfunction, and amyloid-ß peptide (Aß42) toxicity occupies the center stage in the pathogenesis of Alzheimer's disease (AD). The present study examines some of the toxic effects of Aß42 on brain mitochondria and provides evidence that aged brain mitochondria are significantly more vulnerable to Aß42 toxicity. In particular, the study has shown that the aggregated, but not the monomeric, form of Aß42 in varying concentrations (10-40 µM) during in vitro incubation causes a loss of mitochondrial membrane potential, a decrease in phosphorylation capacity and ATP synthesis, and the release of cytochrome c from the mitochondria but without any noticeable change in the activities of respiratory chain complexes. Such effects of Aß42 are strikingly more conspicuous on aged rat (22-24 months) brain mitochondria compared to that on brain mitochondria of young rats (4-6 months). More interestingly is the observation that in contrast to young rat brain mitochondria, a significantly higher level of Aß42 remains associated with aged brain mitochondria under basal incubation condition as well as after exposure to exogenously added peptide. Extrapolated to an in vivo scenario, the results have clear implications in AD pathogenesis and also partly explain why brain aging is a dominant risk factor for this disease condition.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Encéfalo
/
Envejecimiento
/
Péptidos beta-Amiloides
/
Mitocondrias
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
India