Toward functional Ni-SOD biomimetics: achieving a structural/electronic correlation with redox dynamics.
Inorg Chem
; 50(19): 9216-8, 2011 Oct 03.
Article
en En
| MEDLINE
| ID: mdl-21888395
ABSTRACT
We have prepared and characterized a Ni complex with an N(3)S(2) ligand set (1) that represents the first isolable synthetic model of the reduced form of the Ni-SOD (SOD = superoxide dismutase) active site featuring all relevant donor functionality in the proper spatial distribution. As revealed by X-ray crystallography, the axial py-N donor of 1 does not bind Ni(II) in the solid state or in solution like SOD. Oxidation of 1 provides a disulfide-linked dinuclear species, [{Ni(N(3)S(2))}(2)] (2), which we have isolated and characterized. Moreover, the 1 â 2 conversion is reversible, much like redox cycling in the enzyme.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Organometálicos
/
Superóxido Dismutasa
/
Materiales Biomiméticos
/
Níquel
Idioma:
En
Revista:
Inorg Chem
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos