[Preparation and characterization of monoclonal antibodies to Bacillus anthracis protective antigen].
Bioorg Khim
; 37(3): 354-60, 2011.
Article
en Ru
| MEDLINE
| ID: mdl-21899050
ABSTRACT
Anthrax is the widespread acute infection disease, affecting animals and humans, refers to the bioterrorist threat agents of category A, because of the high resistance of Bacillus anthracis spores to adverse environmental factors and the ease of receiving them. We obtain a representative panel of 20 monoclonal antibodies against the key component of pathogenic exotoxins, anthrax protective antigen. Quantitative sandwich-ELISA for protective antigen with antibody obtained was developed. Six pairs of monoclonal antibodies showed the detection limit up to 1 ng/ml concentration of the protective antigen in blood serum.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacillus anthracis
/
Toxinas Bacterianas
/
Carbunco
/
Anticuerpos Monoclonales
/
Antígenos Bacterianos
Límite:
Animals
/
Humans
Idioma:
Ru
Revista:
Bioorg Khim
Año:
2011
Tipo del documento:
Article