Practical considerations of genetic rodent models for neurodegenerative diseases.
Methods Mol Biol
; 793: 185-93, 2011.
Article
en En
| MEDLINE
| ID: mdl-21913101
ABSTRACT
In recent years, the rapid advances in human genetics have identified many genes that are responsible for inherited diseases. In the effort to understand pathogenic pathways and develop therapeutics, researchers have developed genetic animal models as critical tools for the purpose of neurodegenerative disease study. In this overview chapter, we do not intend to cover all the transgenic models for particular diseases, their phenotypical analyses, and their specific usage in this research field. Instead, we outline methods of genetic manipulation and their usage in disease modeling, explain the underlying principles of these methods, and compare the advantages and pitfalls to these different transgenic methods.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Neurodegenerativas
/
Modelos Animales de Enfermedad
Límite:
Animals
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos