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Endogenous retinoids in the hair follicle and sebaceous gland.
Everts, Helen B.
Afiliación
  • Everts HB; Department of Human Nutrition, The Oio State University, 350 Campell Hall, 1787 Neil Ave, Columbus, OH 43210, USA. everts.1@osu.edu
Biochim Biophys Acta ; 1821(1): 222-9, 2012 Jan.
Article en En | MEDLINE | ID: mdl-21914489
ABSTRACT
Vitamin A and its derivatives (retinoids) are critically important in the development and maintenance of multiple epithelial tissues, including skin, hair, and sebaceous glands, as shown by the detrimental effects of either vitamin A deficiency or toxicity. Thus, precise levels of retinoic acid (RA, active metabolite) are needed. These precise levels of RA are achieved by regulating several steps in the conversion of dietary vitamin A (retinol) to RA and RA catabolism. This review discusses the localization of RA synthesis to specific sites within the hair follicle and sebaceous gland, including their stem cells, during both homeostasis and disease states. It also discusses what is known about the specific roles of RA within the hair follicle and sebaceous gland. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Sebáceas / Tretinoina / Folículo Piloso Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glándulas Sebáceas / Tretinoina / Folículo Piloso Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos