Marrying iterative synthesis to cascading radical cyclization: 6-endo/5-exo radical cascade across bis-vinyl ethers.
Org Lett
; 13(20): 5552-5, 2011 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-21919477
ABSTRACT
Application of iterative protocols to the synthesis of functionally and stereochemically complex small molecules is an emerging area of research with the potential to create new efficiencies in complex molecule synthesis. Similarly, the discovery of tandem or cascade reactions can aid in the rapid generation of new structures for biological screening programs. This report describes a cascading 6-endo-trig/5-exo-trig radical cyclization across bis-vinyl ether substrates, which are themselves iteratively synthesized from simple building blocks.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Vinilo
/
Radicales Libres
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2011
Tipo del documento:
Article