Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia.
Leuk Res
; 36(3): 369-76, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-21924771
ABSTRACT
Lack of suitable mouse models for central nervous system (CNS)-associated leukemias has hindered mechanism-guided development of therapeutics. By transplanting retrovirus-transformed mouse erythroleukemia cells into syngeneic mice, we developed a new animal model of meningeal leukemia associated with rapid paralysis. Necropsy revealed massive proliferation of the leukemic cells in the bone marrow (BM) followed by pathological angiogenesis and invasion of the leukemic cells into the meninges of the CNS. Further analysis demonstrated that the erythroleukemia cells secreted high levels of VEGF and preferentially adhered in vitro to fibronectin. This unique animal model for meningeal leukemia should facilitate studies of engraftment and proliferation of leukemic cells in the BM and their invasion of the CNS as well as pre-clinical evaluation of experimental therapeutics for CNS-associated leukemias.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Retroviridae
/
Leucemia Experimental
/
Biomarcadores de Tumor
/
Leucemia Eritroblástica Aguda
/
Neoplasias del Sistema Nervioso Central
/
Modelos Animales de Enfermedad
/
Neoplasias Meníngeas
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Leuk Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos