Serum theophylline analysis by isotope dilution mass spectrometry.
Biomed Environ Mass Spectrom
; 19(6): 360-2, 1990 Jun.
Article
en En
| MEDLINE
| ID: mdl-2192766
ABSTRACT
Serum theophylline analysis was attempted using stable isotope dilution mass spectrometry. Theophylline 15N-labelled in position 7 was used as internal standard. The analysis was performed at resolution 3000 by selected ion monitoring with temperature programming. The sample was introduced in underivatized form by means of the direct inlet probe. Good linearity was obtained in the concentration range 5-40 micrograms ml-1 with relative standard deviations less than 6%. The method is simple and permits six samples to be run per hour. Sensitivity permits analysis at 0.5 micrograms ml-1 at a signal to noise ratio 41.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Teofilina
Límite:
Humans
Idioma:
En
Revista:
Biomed Environ Mass Spectrom
Asunto de la revista:
BIOQUIMICA
Año:
1990
Tipo del documento:
Article
País de afiliación:
Rumanía