Adenovirus vaccine strains genetically engineered to express HIV-1 or HBV antigens for use as live recombinant vaccines.

Hung, P P; Chanda, P K; Natuk, R J; Mason, B B; Chengalvala, M; Bhat, B M; Molnar-Kimber, K L; Dheer, S K; Morin, J E; Mizutani, S

Hung, P P; Chanda, P K; Natuk, R J; Mason, B B; Chengalvala, M; Bhat, B M; Molnar-Kimber, K L; Dheer, S K; Morin, J E; Mizutani, S.

Afiliación

Hung PP; Wyeth-Ayerst Research, Philadelphia, Pa.

Nat Immun Cell Growth Regul ; 9(3): 160-4, 1990.

Article en En | MEDLINE | ID: mdl-2196459

ABSTRACT

ABSTRACT

Types 4 and 7 adenovirus are currently used as live, oral vaccines for the prevention of adenovirus respiratory disease in military recruits. These vaccine strains have been genetically engineered in order to express HIV-1 or HBV antigens in infected cells. A dog model was developed to evaluate the immunogenicity of these recombinant vaccines. Dogs inoculated with live adenovirus-HBV recombinant vaccine produced antibody against hepatitis B surface antigen.

Asunto(s)

Adenoviridae/genética; Antígenos VIH/inmunología; VIH-1/inmunología; Antígenos de la Hepatitis B/inmunología; Vacunas Virales/inmunología; Animales; Perros; Proteína gp120 de Envoltorio del VIH/inmunología; Proteína gp41 de Envoltorio del VIH/inmunología; Antígenos de Superficie de la Hepatitis B/inmunología; Vacunas Sintéticas/inmunología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas Virales / Antígenos VIH / Adenoviridae / VIH-1 / Antígenos de la Hepatitis B Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Animals Idioma: En Revista: Nat Immun Cell Growth Regul Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 1990 Tipo del documento: Article País de afiliación: Panamá

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