Validation of a research case definition of Gulf War illness in the 1991 US military population.
Neuroepidemiology
; 37(2): 129-40, 2011.
Article
en En
| MEDLINE
| ID: mdl-21986258
BACKGROUND: A case definition of Gulf War illness with 3 primary variants, previously developed by factor analysis of symptoms in a US Navy construction battalion and validated in clinic veterans, identified ill veterans with objective abnormalities of brain function. This study tests prestated hypotheses of its external validity. METHODS: A stratified probability sample (n = 8,020), selected from a sampling frame of the 3.5 million Gulf War era US military veterans, completed a computer-assisted telephone interview survey. Application of the prior factor weights to the subjects' responses generated the case definition. RESULTS: The structural equation model of the case definition fit both random halves of the population sample well (root mean-square error of approximation = 0.015). The overall case definition was 3.87 times (95% confidence interval, 2.61-5.74) more prevalent in the deployed than the deployable nondeployed veterans: 3.33 (1.10-10.10) for syndrome variant 1; 5.11 (2.43-10.75) for variant 2, and 4.25 (2.33-7.74) for variant 3. Functional status on SF-12 was greatly reduced (effect sizes, 1.0-2.0) in veterans meeting the overall and variant case definitions. CONCLUSIONS: The factor case definition applies to the full Gulf War veteran population and has good characteristics for research.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Veteranos
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Vigilancia de la Población
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Encuestas y Cuestionarios
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Modelos Estadísticos
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Síndrome del Golfo Pérsico
/
Guerra del Golfo
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
/
Screening_studies
Límite:
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Neuroepidemiology
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Suiza