Over-expressing CYLD augments antitumor activity of TRAIL by inhibiting the NF-κB survival signaling in lung cancer cells.
Neoplasma
; 59(1): 18-29, 2012.
Article
en En
| MEDLINE
| ID: mdl-22017589
ABSTRACT
The death ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in tumor cells. But studies have demonstrated that many tumor cells were resistant to TRAIL-induced apoptosis. CYLD is recognized as a negative regulator of nuclear factor-kappa B(NF-κB) activity. To explore a correlation between CYLD expression and responsiveness to TRAIL in lung cancer cell lines, we established lung cancer cell lines that stably express CYLD. Our data provided the first evidence that increased expression of CYLD directly blocks TRAIL-induced NF-κB activation, and consequently increases TRAIL-induced apoptosis in lung cancer cells. CYLD may act as a therapeutic target of lung cancer. Targeting CYLD, in combination with TRAIL, may be a new strategy to treat lung cancer with high NF-κB activity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
/
FN-kappa B
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Proteínas Supresoras de Tumor
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Ligando Inductor de Apoptosis Relacionado con TNF
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Neoplasias Pulmonares
/
Proteínas de Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Neoplasma
Año:
2012
Tipo del documento:
Article