Protective immunity elicited by a pseudotyped baculovirus-mediated bivalent H5N1 influenza vaccine.
Antiviral Res
; 92(3): 493-6, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22020305
The development of novel H5N1 influenza vaccines to elicit a broad immune response is a priority in veterinary and human public health. In this report, a baculovirus vector was used to construct bivalent recombinant baculovirus vaccine encoding H5N1 influenza virus hemagglutinin proteins (BV-HAs) from clade 2.3.4 and clade 9 influenza viruses. Mice immunized with 5×10(7) IFU BV-HAs developed significantly high levels of H5-specific neutralizing antibodies and cellular immunity that conferred 100% protection against infection with H5N1 influenza viruses. This study suggests that baculovirus-delivered multi-hemagglutinin proteins might serve as a candidate vaccine for the prevention of pre-pandemic and pandemic H5N1 influenza viruses.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas contra la Influenza
/
Baculoviridae
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Infecciones por Orthomyxoviridae
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Subtipo H5N1 del Virus de la Influenza A
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Vectores Genéticos
Límite:
Animals
Idioma:
En
Revista:
Antiviral Res
Año:
2011
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Países Bajos