[Gene therapy in Parkinson disease: a promising future treatment?]. / La thérapie génique dans la maladie de Parkinson : un traitement d'avenir ?
Therapie
; 66(5): 413-9, 2011.
Article
en Fr
| MEDLINE
| ID: mdl-22031685
ABSTRACT
Parkinson disease is a neurodegenerative pathology with high incidence. Current treatments ease the symptoms but don't stop the development of the disease and aren't without any major side effects. Although this pathology is not specifically caused by genetic abnormalities, the involvement of numerous proteins in the pathophysiological process enables us to give an interest to gene therapy. This hypothesis has been upheld by positive results on animals and by five phase I trials on humans but may be attenuated by the first phase II trial recently published showing modest efficiency and multiple side effects. However, these preliminary results will need to be reinforced by more important trials in order to be sure of the safety and get efficacy data, which will allow us to give an opinion upon this new way of treatment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Terapia Genética
Límite:
Humans
Idioma:
Fr
Revista:
Therapie
Año:
2011
Tipo del documento:
Article
País de afiliación:
Francia