[Antimetabolites]. / Les antimétabolites.
Bull Cancer
; 98(11): 1263-74, 2011 Nov.
Article
en Fr
| MEDLINE
| ID: mdl-22049385
ABSTRACT
Antimetabolites are cytotoxic agents, which have been developed for more than 50â years. Which cancer patient did not receive or will not receive 5-fluorouracil or methotrexate during the evolution his or her disease? Antimetabolites are defined as interfering with the synthesis of the DNA constituents; they are structural analogues, either of purine and pyrimidine bases (or the corresponding nucleosides), or of folate cofactors, which are involved at several steps of purine and pyrimidine biosynthesis. Their first mechanism of action is, therefore, to induce depletion in nucleotides inducing in turn an inhibition of DNA replication. However, some of them are able to get inserted fraudulently into nucleic acids, inducing structural abnormalities leading to cell death by other mechanisms, including DNA breaks. We present in this paper, for the three classes of antimetabolites, both ancient and recent molecules as well as molecules still in clinical trials, without exhaustivity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Purinas
/
Pirimidinas
/
Antagonistas del Ácido Fólico
/
Neoplasias
/
Antimetabolitos Antineoplásicos
Límite:
Humans
Idioma:
Fr
Revista:
Bull Cancer
Año:
2011
Tipo del documento:
Article