Application of the Seattle Heart Failure Model in patients on cardiac resynchronization therapy.
Pacing Clin Electrophysiol
; 35(1): 88-94, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22054166
ABSTRACT
BACKGROUND:
The Seattle Heart Failure Model (SHFM) is a multimarker risk assessment tool able to predict outcome in heart failure (HF) patients.AIM:
To assess whether the SHFM can be used to risk-stratify HF patients who underwent cardiac resynchronization therapy with (CRT-D) or without (CRT) an implantable defibrillator. METHODS ANDRESULTS:
The SHFM was applied to 342 New York Heart Association class III-IV patients who received a CRT (23%) or CRT-D (77%) device. Discrimination and calibration of SHFM were evaluated through c-statistics and Hosmer-Lemeshow (H-L) goodness-of-fit test. Primary endpoint was a composite of death from any cause/cardiac transplantation. During a median follow-up of 24 months (25th-75th percentile [pct] 12-37 months), 78 of 342 (22.8%) patients died; seven patients underwent urgent transplantation. Median SHFM score for patients with endpoint was 5.8 years (25th-75th pct 4.25-8.7 years) versus 8.9 years (25th-75th pct 6.6-11.8 years) for those without (P < 0.001). Discrimination of SHFM was adequate for the endpoint (c-statistic always ranged around 0.7). The SHFM was a good fit of death from any cause/cardiac transplantation, without significant differences between observed and SHFM-predicted survival.CONCLUSION:
The SHFM successfully stratifies HF patients on CRT/CRT-D and can be reliably applied to help clinicians in predicting survival in this clinical setting.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Modelos de Riesgos Proporcionales
/
Terapia de Resincronización Cardíaca
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Insuficiencia Cardíaca
Tipo de estudio:
Etiology_studies
/
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Pacing Clin Electrophysiol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia