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The fatty acid amide hydrolase (FAAH) gene variant rs324420 AA/AC is not associated with weight loss in a 1-year lifestyle intervention for obese children and adolescents.
Knoll, N; Volckmar, A-L; Pütter, C; Scherag, A; Kleber, M; Hebebrand, J; Hinney, A; Reinehr, T.
Afiliación
  • Knoll N; Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany.
Horm Metab Res ; 44(1): 75-7, 2012 Jan.
Article en En | MEDLINE | ID: mdl-22068813
Adult obese carriers of the A allele of SNP rs324420 in the fatty acid amide hydrolase (FAAH) gene lose more weight and improve associated phenotypes better than non-carriers during an intervention. We aimed to replicate this finding in obese children and adolescents undergoing a one year lifestyle intervention (Obeldicks program). A total of 453 overweight and obese children and adolescents (10.8±2.6 years, BMI-SDS 2.4±0.5; 55% girls) were genotyped for rs324420 (C/A) by restriction fragment length polymorphism (RFLP) analysis. Participants were prescribed a balanced diet, containing 55 En% carbohydrates, 30 En% fat, and 15 En% proteins. Moreover, they took part in an exercise therapy once a week. Blood was taken at baseline and after 1 year of intervention. Anthropometric (height, weight, BMI, and BMI-SDS) and plasma parameters (total cholesterol, LDL-cholesterol, HDL-cholesterol, triacylglycerides, glucose, insulin, and HOMA) as well as blood pressure were measured. Both mean BMI and BMI-SDS improved significantly. The mean systolic blood pressure was also lowered and concentrations of HDL-cholesterol increased significantly. However, none of the measured changes were associated with FAAH rs324420 AA/AC genotype. We did not detect evidence for an association of FAAH genotypes with weight reduction in overweight and obese children and adolescents. Hence, the previous finding in adults could not be confirmed. As the length (1 year as compared to 3 months) and mode of treatment (hypocaloric diet in adults vs. physical activity plus balanced meals) of the interventions varied, these parameters might have influenced the inconsistent results.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Pérdida de Peso / Polimorfismo de Nucleótido Simple / Dieta / Terapia por Ejercicio / Amidohidrolasas / Estilo de Vida / Obesidad Tipo de estudio: Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Horm Metab Res Año: 2012 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ejercicio Físico / Pérdida de Peso / Polimorfismo de Nucleótido Simple / Dieta / Terapia por Ejercicio / Amidohidrolasas / Estilo de Vida / Obesidad Tipo de estudio: Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Horm Metab Res Año: 2012 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania