Biaryl analogues of teriflunomide as potent DHODH inhibitors.
Bioorg Med Chem Lett
; 21(24): 7268-72, 2011 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-22078215
ABSTRACT
The structure-activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These biaryl derivatives were the result of structure-based design and proved to be potent DHODH inhibitors which in addition showed good antiproliferative activities on peripheral blood mononuclear cells and good efficacies in vivo in the rat adjuvant-induced-arthritis model.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Toluidinas
/
Compuestos de Bifenilo
/
Crotonatos
/
Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH
/
Inhibidores Enzimáticos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
España