Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide.
Photodermatol Photoimmunol Photomed
; 27(6): 328-30, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22092738
ABSTRACT
We report a 68-year-old Japanese man who developed photoleukomelanoderma following prolonged photosensitivity caused by hydrochlorothiazide. He showed complete recovery from the leukomelanoderma with the discontinuation of the responsive drug and with topical application of tacrolimus hydrate and corticosteroid. Histological and immunohistochemical examination revealed that there were no melanin-positive cells in the hypopigmented area, despite the presence of melanocytes. These results and the clinical course indicate that leukomelanoderma is postulated temporary dysfunction of melanocytes. We also conducted a review of previous case reports regarding drug-induced photoleukomelanoderma.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos por Fotosensibilidad
/
Trastornos de la Pigmentación
/
Tacrolimus
/
Corticoesteroides
/
Hidroclorotiazida
/
Inmunosupresores
/
Melanocitos
/
Antihipertensivos
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Photodermatol Photoimmunol Photomed
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
DERMATOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón