Hydrangenone, a new isoprenoid with an unprecedented skeleton from Salvia hydrangea.
Org Lett
; 14(1): 166-9, 2012 Jan 06.
Article
en En
| MEDLINE
| ID: mdl-22133100
ABSTRACT
Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectroscopic methods. The relative and absolute configuration of 1 was assigned by NOESY and X-ray crystallographic analysis and by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed in vitro antiplasmodial activity, with an IC(50) value of 1.4 µM against P. falciparum. A plausible biosynthetic pathway of 1 was also proposed.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Salvia
/
Norisoprenoides
/
Antimaláricos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Irán