Increased pro-inflammatory cytokine production in Down Syndrome children upon stimulation with live influenza A virus.
J Clin Immunol
; 32(2): 323-9, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-22170315
ABSTRACT
PURPOSE:
Children with down syndrome (DS) have an increased susceptibility to infections, due to altered humoral and/or cellular immunity. The aim of this study was to determine the cytokine production in whole blood of children with DS upon stimulation with live influenza A virus.METHODS:
Whole blood of 61 children with DS and 57 of their healthy siblings was stimulated with 2.5 × 10(4) TCID50/ml influenza A virus during 6, 24, and 48 h. TNF-α, IL-1ß, IL-6, IL-8, IL-10, IL-12p70, IFN-α, IFN-γ concentrations, and viral load were measured at all time points.RESULTS:
At most of the time points, TNF-α, IL-1ß, IL-6, and IL-8 concentrations were significantly higher in children with DS following stimulation with live influenza A virus. IFN-α and IFN-γ levels were also significantly higher in the DS group. Viral clearance, however, was equal in both groups.CONCLUSIONS:
Children with DS have an altered immune response to influenza A virus. The production of higher levels of pro-inflammatory cytokines may be responsible for a more severe clinical course of viral disease in these children.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
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Citocinas
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Síndrome de Down
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Mediadores de Inflamación
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
J Clin Immunol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Países Bajos