Cardiovascular fitness is associated with altered cortical glucose metabolism during working memory in É4 carriers.
Alzheimers Dement
; 8(4): 352-6, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22226798
ABSTRACT
BACKGROUND:
The possibility that É4 may modulate the effects of fitness in the brain remains controversial. The present exploratory FDG-PET study aimed to better understand the relationship among É4, fitness, and cerebral metabolism in 18 healthy aged women (nine carriers, nine noncarriers) during working memory.METHODS:
Participants were evaluated using maximal level of oxygen consumption, California Verbal Learning Test, and FDG-PET, which were collected at rest and during completion of the Sternberg working memory task.RESULTS:
Resting FDG-PET did not differ between carriers and noncarriers. Significant effects of fitness on FDG-PET during working memory were noted in the É4 carriers only. High fit É4 carriers had greater glucose uptake in the temporal lobe than the low fit É4 carriers, but low fit É4 carriers had greater glucose uptake in the frontal and parietal lobes.CONCLUSIONS:
We demonstrate that fitness differentially affects cerebral metabolism in É4 carriers only, consistent with previous findings that the effects of fitness may be more pronounced in populations genetically at risk for cognitive decline.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Corteza Cerebral
/
Aptitud Física
/
Apolipoproteína E4
/
Glucosa
/
Memoria a Corto Plazo
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Alzheimers Dement
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos