[Influence of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate on cerebral blood perfusion in rats under experimental pathology conditions].
Eksp Klin Farmakol
; 74(8): 17-22, 2011.
Article
en Ru
| MEDLINE
| ID: mdl-22232909
ABSTRACT
Experiments on rats showed that 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate increases cerebral blood flow in the system of carotid arteries both in intact animals and under conditions of global transient ischemia. In combination with tropoxin, 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate enhances the blood flow in the inner carotid artery of intact rats and the local blood flow under conditions of global transient ischemia. A combination of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate and tropoxin increases baseline cerebral blood flow and decreases the constrictor reaction of cerebral blood vessels to 5HT(2B/2C) receptor agonist meta-chlorophenylpiperazine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Picolinas
/
Compuestos Aza
/
Encéfalo
/
Arteria Carótida Interna
/
Isquemia Encefálica
/
Circulación Cerebrovascular
/
Fármacos Neuroprotectores
/
Compuestos Bicíclicos Heterocíclicos con Puentes
Límite:
Animals
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Asunto de la revista:
FARMACOLOGIA
Año:
2011
Tipo del documento:
Article