Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats.
Thromb Res
; 130(1): 75-80, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22261477
ABSTRACT
OBJECTIVE:
This study was designed to investigate the possible antiplatelet effect of aqueous whole-plant C. aronia syn Azarolus (L) extract using Wistar albino rats as a model. MATERIALS ANDMETHODS:
Forty-two male albino Wistar rats weighing 200 to 250 g were divided into seven groups with six rats in each group. Group 1 served as the control and received equal volumes of distilled water. Groups 2-6 served as the experimental groups and were given C. aronia extract at doses of 100, 200, 500, 1,000, and 2,000 mg/kg, while group 7 served as a positive control and was given aspirin (25mg/kg). All the doses were administered orally once a day and the treatment was continued for seven days. In all groups, at the end of the experimental procedure, blood samples were obtained for platelet function measurements, including PFA-100, thromboxane B2 levels, platelet count, and haematocrit. The bleeding time was determined using a modified tail cutting method described previously.RESULTS:
The aqueous C. aronia syn. Azarolus (L) extract significantly altered the bleeding time and the closure time, as determined by the PFA-100 and thromboxane B2 levels, suggesting significant platelet function inhibition. These effects were observed with C. aronia doses between 100 - 500 mg/kg, which yielded thromboxane B2 levels of 1,000 mg/kg, whereas the higher dose (2,000 mg/kg) produced opposite effects on these parameters.CONCLUSION:
C. aronia syn. Azarolus (L) aqueous extract has antiplatelet effects in Wistar albino rats.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Inhibidores de Agregación Plaquetaria
/
Extractos Vegetales
/
Agregación Plaquetaria
/
Crataegus
Límite:
Animals
Idioma:
En
Revista:
Thromb Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Arabia Saudita