Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4.
FEBS Lett
; 586(4): 319-24, 2012 Feb 17.
Article
en En
| MEDLINE
| ID: mdl-22265692
ABSTRACT
Follistatin-related protein (FRP)/follistatin-like 1 (FSTL1) has multi-specific binding nature especially with TGF-ß superfamily proteins, and thereby modulates organ development. However, its function in immune systems remains unclear. Previously, we reported FRP interacts with CD14, which is known to mediate toll-like receptor 4 (TLR4) signaling. Here, we investigated whether FRP activates TLR4 signaling. Recombinant FRP induced interleukin 6 or interleukin 8 production from target cells in a CD14- and TLR4-dependent manner. Moreover, similar to lipopolysaccharide (LPS), FRP induced tolerance to the second LPS stimulation. FRP has the function of evoking innate immune responses as one of the endogenous TLR4 agonists.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de Lipopolisacáridos
/
Proteínas Relacionadas con la Folistatina
/
Receptor Toll-Like 4
/
Inmunidad Innata
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón