Effect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbits.
Neurosciences (Riyadh)
; 11(2): 88-92, 2006 Apr.
Article
en En
| MEDLINE
| ID: mdl-22266555
ABSTRACT
OBJECTIVE:
To study the effects of deferoxamine on tissue sodium-potassium adenosine triphosphatase (Na+-K+ ATPase) activity on cerebral ischemia in rabbits.METHODS:
We cared for the animals in the Pharmacology Department of the Medical School of Selcuk University in 2004. We used 30, New Zealand, 7-day-old male rabbits in the experiment. We anesthetized all the animals with xylazine hydrochloric acid and ketamine. We divided the rabbits equally into 3 groups. In group 1 (n=10) (sham group), we observed baseline levels, and did not apply ischemia. In group 2 (n=10) (untreated group) we produced cerebral ischemia by clamping the bilateral common carotid arteries for 60 minutes, and in group 3 (n=10), we administered deferoxamine (DFO) 50 mg/kg intravenously immediately after opening the clamps.RESULTS:
The Na+-K+ATPase activity increased after DFO treatment (p=0.045).CONCLUSION:
We conclude that Na+-K+ATPase activity in cortical brain tissue was higher in DFO-treated rabbits compared with untreated animals after ischemia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Neurosciences (Riyadh)
Asunto de la revista:
NEUROLOGIA
Año:
2006
Tipo del documento:
Article