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Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer--systematic review and meta-analysis of trends by time and region.
Mehanna, Hisham; Beech, Tom; Nicholson, Tom; El-Hariry, Iman; McConkey, Christopher; Paleri, Vinidh; Roberts, Sally.
Afiliación
  • Mehanna H; Institute of Head and Neck Studies and Education, Coventry, United Kingdom. Hisham.Mehanna@uhcw.nhs.uk
Head Neck ; 35(5): 747-55, 2013 May.
Article en En | MEDLINE | ID: mdl-22267298
BACKGROUND: Little information has been reported on regional and time trends of human papillomavirus (HPV) prevalence rates of oropharyngeal cancer (OPC) and non-OPC. METHODS: The study consisted of a systematic review and meta-analysis using random effects logistic regression models. RESULTS: Overall HPV prevalence in OPC (47.7%; 95% confidence interval [CI], 42.9-52.5%) increased significantly over time: from 40.5% (95% CI, 35.1-46.1) before 2000, to 64.3% (95% CI, 56.7-71.3) between 2000 and 2004, and 72.2% (95% CI, 52.9-85.7) between 2005 and 2009 (p < .001). Prevalence increased significantly in North America and Europe, and the significant gap between them that existed before 2000 (50.7% vs 35.3%, respectively, p = .008) has now disappeared (69.7% vs 73.1%, respectively, p = .8). Prevalence in non-OPC (21.8%; 95% CI, 18.9-25.1%) has not increased over time (p = .97). CONCLUSIONS: The sharp increase in the proportion of HPV-positive OPC over the last decade has occurred at a faster rate in Europe compared with that in North America. In contrast, the relatively low prevalence of HPV in non-OPC remains unchanged.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecciones por Papillomavirus / Neoplasias de Cabeza y Cuello Tipo de estudio: Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Humans País/Región como asunto: America do norte / Europa Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2013 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Orofaríngeas / Infecciones por Papillomavirus / Neoplasias de Cabeza y Cuello Tipo de estudio: Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Humans País/Región como asunto: America do norte / Europa Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2013 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos