Heritability of corneal refraction and corneal astigmatism: a population-based twin study among 66- to 79-year-old female twins.
Acta Ophthalmol
; 91(2): 140-4, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-22280520
ABSTRACT
PURPOSE:
To examine the heritability of corneal refraction power (CR) and corneal astigmatism (AST) in older women.METHODS:
Corneal refraction and AST were measured by IOL master in 52 monozygotic (MZ) and 47 dizygotic (DZ) female twin pairs aged 66-79 years. The relative contribution of genetic and environmental factors to individual differences in CR was estimated by applying an independent pathway model to the twin data and AST by intraclass correlations (ICC).RESULTS:
For the right eye, mean CR was 44.58 dioptres (D) (standard deviation (SD) ±1.28) When comparing CR of the right and left eye between MZ and DZ, no significant difference was found. Mean AST was 0.77 D (SD ±0.44) with no differences observed either between the MZ and the DZ individuals, or between the left and the right eyes. ICCs between the sisters for CR were, for the right eye, 0.882 and 0.378 for MZ and DZ, respectively, and for the left eye 0.855 and 0.358. For AST of the right eye, the ICCs were 0.533 and 0.096 for the MZ and DZ pairs, respectively, and for the left eye, the MZ and DZ correlations were 0.396 and 0.299. Quantitative genetic modelling showed that 81% of the variance in CR could be explained by genetic factors, additive genetic factors explaining 62% (95% confidence interval [CI] 44% -86%) and dominant genetic effect 19% (95% CI 7-49%) of the variance in CR. Different models were constructed to explain the heredity of AST. None of these models gave meaningful results, although the ICC values for MZ were higher than those for DZ.CONCLUSIONS:
Most of the variance in CR among older Finnish women could be explained by genetic factors.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Refracción Ocular
/
Astigmatismo
/
Gemelos Dicigóticos
/
Gemelos Monocigóticos
/
Enfermedades en Gemelos
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Acta Ophthalmol
Asunto de la revista:
OFTALMOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Finlandia