Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging.
Bioorg Med Chem Lett
; 22(4): 1602-5, 2012 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-22281185
ABSTRACT
(19)F-modified bithiazole correctors and phenylglycine potentiators of the ΔF508-CFTR chloride channel were synthesized and their function assayed in cells expressing human ΔF508-CFTR and a halide-sensitive fluorescent protein. Fluorine was incorporated into each scaffold using prosthetic groups for future biodistribution imaging studies using positron emission tomography (PET). The ΔF508-CFTR corrector and potentiator potencies of the fluorinated analogs were comparable to or better than those of the original compounds.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Radioisótopos de Flúor
/
Regulador de Conductancia de Transmembrana de Fibrosis Quística
/
Tomografía de Emisión de Positrones
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos