Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania.
Int J Tuberc Lung Dis
; 15(10): 1380-9, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-22283899
ABSTRACT
BACKGROUND:
Patients with tuberculosis (TB) often suffer from profound malnutrition.OBJECTIVE:
To examine the patterns and predictors of change in nutritional and hemoglobin status during and after TB treatment.METHODS:
A total of 471 human immunodeficiency virus (HIV) positive and 416 HIV-negative adults with pulmonary TB were prospectively followed in Dar es Salaam, Tanzania. All patients received 8 months' TB treatment following enrollment.RESULTS:
About 40% of HIV-positive and 47% of HIV-negative TB patients had body mass index (BMI) < 18.5 kg/m 2 at baseline, while about 94% of HIV-positive and 84% of HIV-negative participants were anemic at baseline. Both HIV-positive and HIV-negative patients experienced increases in BMI and hemoglobin concentrations over the course of TB treatment. Among HIV- positive patients, older age, low CD4 cell counts, and high viral load were independently associated with a smaller increase in BMI from baseline to 8 months. Fe- male sex, older age, low CD4 cell counts, previous TB infection and less money spent on food were independently associated with a smaller improvement in hemoglobin levels among HIV-positive patients during treatment.CONCLUSION:
HIV-positive TB patients, especially those with low CD4 cell counts, showed poor nutritional recovery during TB treatment. Adequate nutritional support should be considered during TB treatment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis Pulmonar
/
Hemoglobinas
/
Estado Nutricional
/
Desnutrición
/
Anemia
/
Antituberculosos
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
/
Patient_preference
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos