Synthesis of cyclopentapyridine and thienopyridine derivatives as potential calcium channel modulators.
Arzneimittelforschung
; 62(4): 167-75, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-22286976
ABSTRACT
In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridinas
/
Canales de Calcio
/
Ciclopentanos
/
Tienopiridinas
Límite:
Animals
Idioma:
En
Revista:
Arzneimittelforschung
Año:
2012
Tipo del documento:
Article
País de afiliación:
Turquía