Reported intake of selected micronutrients and risk of colorectal cancer: results from a large population-based case-control study in Newfoundland, Labrador and Ontario, Canada.
Anticancer Res
; 32(2): 687-96, 2012 Feb.
Article
en En
| MEDLINE
| ID: mdl-22287764
ABSTRACT
AIM:
The impact of micronutrient intake and colorectal cancer (CRC) risk is poorly understood. The objective of this study was to evaluate the associations of selected micronutrients with risk of incident CRC in study participants from Newfoundland, Labrador (NL) and Ontario (ON), Canada. MATERIALS ANDMETHODS:
We conducted a population-based study among 1760 case participants and 2481 age- and sex-matched control participants. Information on diet and other lifestyle factors were measured using a food frequency questionnaire and a personal history questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, controlling for covariables.RESULTS:
Highest compared to lowest quartile intakes of certain micronutrients were associated with lower risk of CRC, including calcium (from food and supplements (FS), OR=0.59; 95% CI=0.45-0.77, and from food only (FO) OR=0.76, 95% CI=0.59-0.97), vitamin C (FSOR=0.67; 95%CI0.51-0.88), vitamin D (FS OR=0.73; 95% CI 0.57-0.94, FO OR=0.79, 95% CI=0.62-1.00), riboflavin (FS OR=0.61; 95% CI=0.47-0.78, and folate (FS OR=0.72; 95% CI=0.56-0.92). Higher risk of CRC was observed for iron intake (highest versus lowest quintiles OR=1.34, 95% CI=1.01-1.78).CONCLUSION:
This study presents evidence that dietary intake of calcium, vitamin D, vitamin C, riboflavin and folate are associated with a lower risk of incident CRC and that dietary intake of iron may be associated with a higher risk of the disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Micronutrientes
/
Suplementos Dietéticos
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Anticancer Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Canadá