Neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years.
J Pediatr Endocrinol Metab
; 24(11-12): 897-902, 2011.
Article
en En
| MEDLINE
| ID: mdl-22308839
ABSTRACT
CONTEXT Hypothyroxinemia in premature neonates may affect long-term neurodevelopment. OBJECTIVE:
This study aimed to examine the effects of hypothyroxinemia of the newborn preterm infants born at 28-36 weeks of gestational age (GA) on the neurodevelopment at 4 years of age. PATIENTS Prospective observational cohort study conducted in Madrid, Spain. Forty-six preterm infants were included in the study. MAINOUTCOME:
The effects of the exposure to neonatal hypothyroxinemia on mental development were examined.RESULTS:
Using regression analyses we found that neonatal T4 had a positive association with general cognitive index and Verbal index, and neonatal FT4 with general cognitive and Memory indexes at 4 years of age.CONCLUSIONS:
The exposure to hypothyroxinemia during the neonatal period of late preterm infants may play role in neurodevelopmental delays. Higher T4 level means a trend to higher indexes and low T4 level means a lower neurodevelopmental indexes at 4 years of age.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Recien Nacido Prematuro
/
Desarrollo Infantil
/
Cognición
/
Hipotiroidismo
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Child, preschool
/
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
España