Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
J Nat Prod
; 75(2): 249-56, 2012 Feb 24.
Article
en En
| MEDLINE
| ID: mdl-22329624
ABSTRACT
Eleven new dibenzocyclooctadiene lignans, polysperlignans A-K (1-11), and eight known analogues (12-19) were isolated from the stems of Kadsura polysperma. Their structures and absolute configurations were established using a combination of MS, NMR, CD, and single-crystal X-ray diffraction techniques. Selected compounds were evaluated for activity against ß-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, and 1, 2, 4, 5, 13, and 16 showed statistically significant neuroprotective effects in these in vitro assays.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
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Lignanos
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Fármacos Neuroprotectores
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Kadsura
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Ciclooctanos
Límite:
Animals
Idioma:
En
Revista:
J Nat Prod
Año:
2012
Tipo del documento:
Article