[Comparative experimental studies of the combined use of vaccines, interferon and interferon inducers in neurovirus infections]. / Sravnitel'nye issledovaniia po éksperimental'nomu izucheniiu sochetannogo primeneniia vaktsin, interferona i induktorov interferona pri nekotorykh neirovirusnykh infektsiiakh.
Vopr Virusol
; (3): 262-7, 1979.
Article
en Ru
| MEDLINE
| ID: mdl-223329
ABSTRACT
Comparative investigations of the combined use of vaccines and interferon in tick-borne encephalitis, herpes, and acute encephalomyelitis of man showed that up to 78% of animal protection against 10--50 LD50 of intraperitoneally inoculated viruses could be achieved. Vaccination alone provided up to 56% survival of the infected mice, while administration of interferon subcutaneously or intraperitoneally in a dose of 800 units (53,300 units per 1 kilo body weight) 18--20 hours before virus gave a survival rate of 36%. The use of vaccine in combination with an interferon inducer, phage of f2 RNA, in tick-borne encephalitis gave up to 75% survival of the infected mice. Four hours after administration, interferon could be detected in mouse sera in a concentration up to 640 units/ml which in immune mice accumulated more rapidly and remained at a higher level 18 hours after inoculation of the inducer.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virosis
/
Vacunas Virales
/
Inductores de Interferón
/
Interferones
Límite:
Animals
Idioma:
Ru
Revista:
Vopr Virusol
Año:
1979
Tipo del documento:
Article