Tissue and cellular distribution of gold nanoparticles varies based on aggregation/agglomeration status.
Nanomedicine (Lond)
; 7(2): 199-209, 2012 Feb.
Article
en En
| MEDLINE
| ID: mdl-22339133
ABSTRACT
AIM:
The ability of nanoparticles to form larger superstructures of aggregates and agglomerates has been extensively noted in the literature. The in vivo biological impact of these structures, however, has not been assessed. This knowledge gap is especially critical in the safety assessment of nanoparticles to be used for therapeutic purposes. METHOD/RESULTS:
Here we show that when administered intravenously into a mouse model, gold nanoparticle superstructures of reversible agglomerates and irreversible aggregates demonstrate significant differences in organ and cellular distribution compared with the primary particle building blocks. In addition, different structures produced different blood serum chemistry data.CONCLUSION:
These findings raise the possibility for different mechanisms of toxicity between the structures. Such a possibility necessitates complete characterization and stability assessment of nanomaterials prior to their in vivo administration.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Análisis Químico de la Sangre
/
Nanopartículas
/
Oro
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos