Glutamatergic neurotransmission as molecular target of new anticonvulsants.
Curr Top Med Chem
; 12(9): 971-93, 2012.
Article
en En
| MEDLINE
| ID: mdl-22352860
ABSTRACT
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) controlling physiological processes as learning and memory. However, the overactivation of glutamatergic neurotransmission is often related to various CNS chronic and acute diseases (epilepsy, ischaemia, Parkinson, etc.). This review will focus on the chemical structures, mechanism of action and main structure-activity relationships of anticonvulsant agents acting through glutamate neurotransmission.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades del Sistema Nervioso Central
/
Transmisión Sináptica
/
Glutamatos
/
Anticonvulsivantes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Top Med Chem
Asunto de la revista:
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia