Amorimia exotropica poisoning as a presumptive cause of myocardial fibrosis in cattle.
J Vet Diagn Invest
; 23(6): 1226-9, 2011 Nov.
Article
en En
| MEDLINE
| ID: mdl-22362807
ABSTRACT
The current study reports the investigation on the cause of sudden deaths associated with cardiac fibrosis in cattle in northern Rio Grande do Sul, Brazil. The exclusion of known causes of bovine cardiac fibrosis as well as the absence of the plants in that region whose consumption has already been linked to the disorder motivated this investigation. The condition, which was attributed to the consumption of Amorimia exotropica, affected draft oxen, most of which died suddenly without showing any clinical signs during usual management or work. Globular hearts with white foci at their cut surfaces were the main gross findings, which corresponded microscopically from multifocal to coalescent areas of myocardial fibrosis. To confirm the condition, A. exotropica from the ranches where cattle died from the disease was dosed to rabbits, which showed similar lesions to those seen in dead cattle after receiving 10 doses of 3.6 g/kg at 4-day intervals. Electron microscopy on rabbit tissues revealed severe tumefaction of the cardiomyocytes associated with mitochondrial swelling, displacement, and rupture of the mitochondrial crests, and of the bundles of myofibrils, apart from large glycogen deposits within the sarcoplasm. It is suggested that mitochondrial changes triggered alterations that lead to cardiac fibrosis and that all of these changes were induced by A. exotropica cardiotoxicity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plantas Tóxicas
/
Fibrosis
/
Enfermedades de los Bovinos
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Malpighiaceae
/
Cardiopatías
Límite:
Animals
Idioma:
En
Revista:
J Vet Diagn Invest
Asunto de la revista:
MEDICINA VETERINARIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Brasil