Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality.
Subcell Biochem
; 59: 271-87, 2012.
Article
en En
| MEDLINE
| ID: mdl-22374094
ABSTRACT
An interface coordinating lipid metabolism with proteins that regulate membrane trafficking is necessary to regulate Golgi morphology and dynamics. Such an interface facilitates the membrane deformations required for vesicularization, forms platforms for protein recruitment and assembly on appropriate sites on a membrane surface and provides lipid co-factors for optimal protein activity in the proper spatio-temporally regulated manner. Importantly, Sec14 and Sec14-like proteins are a unique superfamily of proteins that sense specific aspects of lipid metabolism, employing this information to potentiate phosphoinositide production. Therefore, Sec14 and Sec14 like proteins form central conduits to integrate multiple aspects of lipid metabolism with productive phosphoinositide signaling.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Fosfatos de Fosfatidilinositol
/
Proteínas de Saccharomyces cerevisiae
/
Proteínas de Transferencia de Fosfolípidos
/
Metabolismo de los Lípidos
/
Aparato de Golgi
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Subcell Biochem
Año:
2012
Tipo del documento:
Article