[Common variable immunodeficiency: an update on etiology, pathophysiology, and classification].
Nihon Rinsho Meneki Gakkai Kaishi
; 35(1): 14-22, 2012.
Article
en Ja
| MEDLINE
| ID: mdl-22374438
ABSTRACT
Common variable immunodeficiency is one of the most common primary immunodeficiency that is categorized into primary antibody deficiency. The responsible genes identified so far include ICOS, TACI, CD19, CD20, CD21, CD81 and BAFF-R; and most of the CVID-causing genes are yet to be identified. TACI mutation is the most common one; however the direct contribution of TACI mutation to pathogenesis of CVID is not yet clear. One third to a half of the patients with CVID shows autoimmunity as well as malignancy in their course. It is of importance to develop diagnostic measure, to identify the disease causing genes, and to develop the optimal therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunodeficiencia Variable Común
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
Ja
Revista:
Nihon Rinsho Meneki Gakkai Kaishi
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2012
Tipo del documento:
Article
Pais de publicación:
JAPAN
/
JAPON
/
JAPÃO
/
JP