Premature aging syndrome.
Adv Exp Med Biol
; 724: 317-31, 2012.
Article
en En
| MEDLINE
| ID: mdl-22411253
ABSTRACT
Hutchinson-Gilford progeria syndrome and Werner syndrome are two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. Both disorders have been the focus of intense research in recent years since they might provide insights into the pathology of normal human aging. The chapter contains a detailed description of the clinical features of both disorders and then it focuses on the genetics, the resulting biochemical alterations at the protein level and the most recent findings and hypotheses concerning the molecular basis of the premature aging phenotypes. A description of available diagnostic and therapeutic approaches is included.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progeria
/
Síndrome de Werner
/
Envejecimiento Prematuro
Límite:
Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Italia