Plasma and synovial fluid connective tissue growth factor levels are correlated with disease severity in patients with knee osteoarthritis.
Biomarkers
; 17(4): 303-8, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22416876
ABSTRACT
BACKGROUND:
Connective tissue growth factor (CTGF) has been implicated in development of osteoarthritis (OA).OBJECTIVE:
To determine the correlation between plasma and synovial fluid CTGF levels and the severity in knee osteoarthritis patients.METHODS:
A total of 100 subjects were recruited into this study (75 OA patients and 25 controls). CTGF concentrations in plasma and synovial fluid were analyzed by enzyme-linked immunosorbent assay.RESULTS:
Plasma and synovial fluid CTGF concentrations were correlated with radiographic severity. There was a positive correlation between plasma and synovial fluid CTGF levels.CONCLUSION:
CTGF could be useful for monitoring the severity and progression of OA.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Líquido Sinovial
/
Osteoartritis de la Rodilla
/
Factor de Crecimiento del Tejido Conjuntivo
/
Articulación de la Rodilla
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biomarkers
Asunto de la revista:
BIOQUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Tailandia