Oxidative capacity and fatigability in run-trained malignant hyperthermia-susceptible mice.
Muscle Nerve
; 45(4): 586-96, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-22431093
ABSTRACT
INTRODUCTION:
The purpose of this study was to test the hypothesis that malignant hyperthermia model mice (RyR1Y522S/wt) are more vulnerable to exercise-induced muscle injury and fatigability and adapt less to run training.METHODS:
After 6 weeks of voluntary wheel running, we measured anterior crural muscle fatigability, muscle injury, and cytochrome oxidase (COX) and citrate synthase (CS).RESULTS:
Although RyR1Y522S/wt mice ran without undergoing MH episodes, they ran 42% less distance than wild-type (WT) mice. Muscles from WT mice exhibited increased fatigue resistance and COX content after training. Muscles from RyR1Y522S/wt mice demonstrated no significant change in fatigability or COX and CS after training. However, muscles from RyR1Y522S/wt mice displayed less intrinsic fatigability and greater COX/CS content and muscle damage than WT mice.CONCLUSIONS:
RyR1Y522S/wt mice can run without having rhabdomyolysis, and their inability to adapt to training appears to stem from intrinsic enhancement of mitochondrial enzymes and fatigue resistance.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Condicionamiento Físico Animal
/
Músculo Esquelético
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Fatiga Muscular
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Hipertensión Maligna
Límite:
Animals
Idioma:
En
Revista:
Muscle Nerve
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos