Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.
Org Biomol Chem
; 10(17): 3448-54, 2012 May 07.
Article
en En
| MEDLINE
| ID: mdl-22434259
ABSTRACT
A 6-step procedure was developed for the synthesis of a new family of acyclic nucleoside phosphonates (ANPs), "PHEEPA" [(2-pyrimidinyl-2-(2-hydroxyethoxy)ethyl)phosphonic acids] in overall yields ranging from 4.5% to 32%. These compounds, which possess on one side a hydroxy function and on the other side a phosphonate group, can be considered either as potential antiviral agents or as transition state analogues of nucleoside phosphorylases such as thymidine phosphorylase.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirimidinas
/
Timidina Fosforilasa
/
Materiales Biomiméticos
/
Técnicas de Química Sintética
/
Organofosfonatos
/
Nucleósidos
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Francia